Thomas Partey has been handed a starting role in Coach Avram Grant's team against the Cranes of Uganda while Jonathan Mensah has been dropped to the bench.
The Athletico Madrid player will be playing in his first Africa Cup of Nations with the Black Stars and hope to keep his starting role.
Daniel Amartey will join John Boye, Harrison Afful and Baba Rahman to complete the back four while Mubarak Wakaso, Andre Ayew, Jordan Ayew, Asamoah Gyan, Christian Atsu and Razak Briamah completes the starting XI for Ghana.