Boca manager Guillermo Barros Schelotto has parted ways with the club after heir defeat in the Copa Libertadores final by nemesis River Plate.
Boca Juniors, in the Copa Libertadores final lost 3-1 in extra time to arch-rivals River Plate on Sunday's second leg in Madrid.
The big encounter was relocated to Madrid in Spain after River fans attacked the Boca bus and injured players before their second leg in Buenos Aires.
"Beyond the pain of not having won the cup, I'm going with peace of mind of having given everything," the former Argentina international said.
Club president Daniel Angelici added: "Though the pain and sadness have not yet gone, we understand that the best thing for Boca is a change, to start the year with a new coach."
His reign ended with one of the biggest games in South American football history - as Buenos Aires' big rivals met in the continent's version of the Champions League final for the first time.