Hearts of Oak will welcome Medeama SC to the Accra Stadium today, Saturday, April 2 in the Ghana Premier League matchjday 23 fixture.
The Phobians will be seeking revenge after succumbing to a 1-0 defeat to the Tarkwa based side in the first round of the league.
Coach Samuel Boadu's side in midweek picked a point against Berekum Chelsea at the Golden City park while Medeama defeated King Faisal by 1-0 at the Akoon Park on Thursday.
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The defending champions are currently behind Medeama on the league table with 33 points on the seventh position.
A win could see them level up on points with the Tarkwa-based side currently occupying the sixth position with 36 points.
Hearts of Oak defeated Medeama 2-0 in their last visit to the Accra Sports Stadium in a league game in the 2020/21 season.