A Spanish top-flight game will be played in the US, the first time a La Liga match has taken place overseas.
The plan is part of a 15-year partnership between La Liga and media company Relevent, which organises the International Champions Cup, to promote football in North America.
La Liga president Javier Tebas called it a "ground-breaking agreement".
The Premier League has previously discussed plans to play a '39th game' outside England and Wales.
The idea drew criticism from fans and the media, and executive chairman Richard Scudamore, who proposed the idea in 2008, said it could not happen "until the conditions are right".
Asked when the US-based match would take place and whether it would be a regular fixture, La Liga told BBC Sport it "can not confirm the teams, match, date or season".
Tebas has previously said El Clasico, between Real Madrid and Barcelona, would "never be played outside of Spain".
But a friendly between the two clubs was played in Miami in July 2017, as part of the International Champions Cup - the first time the fixture had been played outside Spain since 1991.