Primenewsghana have compiled the five matches not to be missed this weekend from around the globe.
1. Tottenham Hotspur vs ChelseaCapital clash to stay in touch at the top
Unbeaten Chelsea travels to Tottenham, looking for only their second away win against their London rivals since 2013. The last three meetings between the sides have produced 13 goals, and the away side has won the last two. Can Chelsea become the third Top Six side to win at Wembley this season and heap more pressure on Mauricio Pochettino? Make sure you're wearing a seatbelt.  
2. Manchester United vs Crystal PalaceÂ
Red Devils must bounce back from derby disappointment
It's been a strange season for Manchester United and their supporters. In a way, the past two weeks have summed it up perfectly; a historic win at Juventus was followed by a humbling defeat in the Manchester Derby. José Mourinho must get his side back on track against Crystal Palace, who will have United old boy Wilfried Zaha in their ranks and looking to prove a point.
3. Fulham vs Southampton
Relegation six-pointer
Remember when Claudio Ranieri won the EPL title with Leicester in 2016? Well, he's back in England and his assignment this time around is to drag Fulham out of the relegation zone. The mission starts this weekend against fellow strugglers Southampton where both sides will be desperate for a precious three points. 
4. Atlético Madrid vs Barcelona
Tussle for top spot in Spain
The Europa League Champions host the champions of Spain in a fixture that hasn't produced a goalless draw since 2013. Hosts Atlético trail Barcelona by a point going into the match, meaning that a win would propel them to the summit of LaLiga. It won't be easy, however, with Lionel Messi back to full fitness. This one is not to be missed, especially with Diego Simeone looking for his first ever league win over the champions. Get ready for the left-footers showdown. Griezmann vs Messi. Atléti vs Barca. 
5. Kaizer Chiefs vs Orlando Pirates
Soweto Derby bragging rights on the lineÂ
It's always a huge occasion when Amakhosi take on The Buccaneers, and on Saturday, South Africa's two most followed clubs will face off in the Telkom Knockout Semifinals at Moses Mabhida Stadium. Only one of these giants can progress to the final, can Chiefs avenge last month's defeat to Pirates in the PSL?
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