The Egyptian Football Association (EFA) has withdrawn from participating in the 2018 African Nations Championship (CHAN), slated for January in Morocco.
Morocco replaced Kenya as host of the competition after they were stripped off the hosting rights.
Egypt were beaten by Morocco in the Northern Zone playoffs and were allowed entry into the tournament when Morocco were given the rights to host.
"We have sent an official letter to the African Football Confederation (CAF), informing them that we will not be able to take part in the upcoming African Nations Championship (CHAN), Egypt FA executive Director Tharwat Sweilam said.
"The reason for the apology is that we can't stop the Premier League, especially as the tournament is being played outside the FIFA international agenda.
"There are special youth players such as Ahmed Fetouh of Zamalek, Al Ahly's Akram Tawfik, Kasim Nedved and Ahmed Ramadan Beckham, but they will join the Olympic team and at the same time they are registered with their teams in the Premier League, " he added.
The CHAN is the sole reserve for players who ply their trade locally.
If the request of the EFA is granted, CAF will replace Egypt with another country to complete the 16 nations for tournament.
Ghana failed to qualify for the tournament and could take advantage of the situation and participate.