Substitute Marko Arnautovic scored the only goal of a game his introduction changed as Inter Milan beat Atletico Madrid 1-0 in the first leg of their UEFA Champions League last-16 tie.
After a sluggish first half, Inter were much improved and Arnautovic had two great chances soon after coming on at the break, but on both occasions the Austrian shot over from close range.
It was third time lucky for the forward however as he tucked home a 79th-minute rebound, with the chance stemming from an Atletico Madrid mix-up in the midfield.
Alvaro Morata returned from a knee problem for Atleti in the second half but was not at his best, while Antonie Griezmann exiting with an apparent injury of his own will be a concern.
Last season's runners-up were good value for their victory but may feel they should have won by a wider margin, especially with a trip to the Metropolitano Stadium - where Diego Simeone's team have lost just once this season - to come.