Rescuers are looking for survivors after a massive flash flood on the Nepal-Tibet border destroyed homes, swamped roads, and swept away bridges.
More than 900 people are missing and at least 332 have died in Nepal.
Two sisters are desperately waiting for news of their parents, who travelled from Texas to Tibet on a pilgrimage: "We just love them a lot and want them to come home," they tell the BBC.
In Tibet, at least 558 people are missing, with three confirmed dead - it's not clear if these figures overlap with Nepal's.
On both sides of the border, hundreds of foreign nationals are missing - Nepal says that includes 178 tourists from India, 127 from Nepal, 65 Americans, 35 Australians, and 33 from the UK.
The US Geological Survey says "glacial collapse and debris flow" triggered the floods - and there are fears of more floods, with debris blocking rivers.
Over 900 people missing, including 517 foreign citizens, says Nepal disaster agency
Nepal's National Disaster Risk Reduction and Management Authority says 910 people are missing and remain uncontactable following the floods.
This includes 517 foreign citizens, 44 members of the Nepal Army and 28 Nepal police officers.
It adds that 258 bodies have been recovered so far, while 351 people have been rescued.
In our latest update, we reported figures from Nepal police saying the death toll has reached 289. Both organisations have been providing separate updates on the rescue operation as it develops.
Burnham pledges £5m support package to Nepal
Prime Minister Andy Burnham says the UK has pledged £5 million to help with the response effort in Nepal following the flash floods on Wednesday.
"It’s a devastating picture that is emerging from what has happened in Nepal," Burnham says during a visit to South Wales.
"Immediate action" is being taken and the UK is deploying consular support staff to the region "so that British nationals will be able to access support 24/7", he adds. The latest from Nepali police is that 33 UK nationals are currently missing.
“Obviously, there are a number of British nationals who currently are thought to be missing and we’ll be providing all the support we can to their families in what is a very distressing and devastating situation," he adds.
Burnham says the UK has also offered to send emergency responders to the region, but "that’s obviously a matter for the Nepalese government".
'We just want them to come home' - sisters seek information on missing parents
Sisters Ashna and Shreya Ahuja are desperately waiting for news of their parents after flash floods struck Nepal.
Deepak and Madhu Ahuja had travelled from Texas to Mount Kailash on a group pilgrimage organised by the spiritual group Isha Foundation to celebrate Deepak's 60th birthday.
The couple had completed the trip and were crossing from Tibet into Nepal when floods hit near the border, their daughters say.
One of the siblings spoke to their parents just hours before the floods.
The sisters have contacted the US State Department and US embassies in Delhi, Nepal and China, but they say they have no concrete information on the whereabouts of their parents.
“It’s only been one day, but it has felt like much longer,” the sisters tell the BBC. “We just love them a lot and want them to come home.”
BBC