Mohammed Kudus scored twice as the Black Stars were held to a 2-2 stalemate against Egypt on Thursday in their second AFCON 2023 game.
Kudus blasted in to put Ghana ahead in first-half stoppage time, a minute after Pharaohs captain Mohamed Salah was forced off through injury.
Omar Marmoush levelled but West Ham's Kudus quickly restored the Black Stars' lead with a deflected effort.
However, Mostafa Mohamed stabbed in to give Egypt their second point and leave Ghana winless after two Group B games.
There were late chances at either end to win it, with Ghana goalkeeper Richard Ofori saving Emam Ashour's shot, before Pharaohs keeper Mohamed El Shenawy failed to clear a corner which Iddrisu Baba could not divert goalwards.
The Black Stars lost their opening game against Cape Verde and the four-time continental champions are on the brink of a second successive group-stage exit from the AFCON and will have to beat Mozambique in the final round of games on Monday to progress to the last 16.
Cape Verde will secure top spot in Group B if the islanders beat Mozambique on Tuesday (14:00 GMT).
The 24-team format means three points may be enough to qualify as one of four best third-placed sides but Egypt, who could be without Salah, may need all three points against Cape Verde.