Liverpool lose 1-0 to Swansea City at the Liberty Stadium in Wales in a Monday night English Premier League game.
Liverpool beat Manchester City 4-3 at Anfield and were full of confidence going into the game.
Alfie Mawson's 40th-minute goal ended Liverpool's 15-game unbeaten run in the Premier League.
Mawson punished a tame defensive header from Virgil van Dijk - who was making his Premier League debut for the Reds - five minutes before half-time to hand the Swans a vital victory in their battle against the drop.
Liverpool pushed for an equaliser but failed to build on their thrilling win over Manchester City as Roberto Firmino struck the post and Mawson blocked Adam Lallana's rebound in a thrilling finale in stoppage-time.
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Lukasz Fabianski bravely smothered Sadio Mane's effort on nine minutes before he could convert from Emre Can's lofted through ball, while Martin Olsson hacked Firmino's goal-bound effort off the line five minutes later.
Swansea were on the back foot but had the ball in the Liverpool net as Jordan Ayew fired home from a narrow angle on 17 minutes, but it was chalked off after the officials spotted the ball had gone out of play.
Salah and substitute Danny Ings drew fine saves from the inspired Fabianski before Firmino headed against the post deep into added time and Mawson's stunning intervention prevented Lallana from converting the rebound.
But the night belonged to Swansea as they moved level with 19th-placed West Brom at the bottom of the table and three points from safety, while Liverpool missed the chance to go third and remain fourth.
Swansea vs Liverpool Man of the Match - Alfie Mawson
On the night when Van Dijk made him Premier League debut for Liverpool, it was his opposing number who stole the headlines. The Swansea centre-back was outstanding throughout, setting the tone at the heart of a battling defensive unit.