The Black Stars won an exhilarating match 3-2 packed with twists and turns against South Korea in front of a vibrant crowd at Education City Stadium in Qatar.
A 10-minute spell by the African nation in the first half gave them with a 2-0 lead courtesy of goals from Southampton defender Mohammed Salisu and Ajax's Mohammed Kudus.
However, noisy celebrations by Ghana fans at half time were dampened by a South Korea comeback after the break.
Two stunning headers in three minutes from Cho Gue-sung, top-scorer in his domestic league, levelled the game after 61 minutes.
But Kudus, who had headed in Jordan Ayew's cross in the first half, added a final twist when he thumped in a third for the Black Stars to break South Korea's hearts.
Chances continued to fall South Korea's way as they searched for another equaliser but, despite 10 minutes of added time, Ghana held on.
There were emotional scenes at the final whistle as many South Korea players fell to the ground while manager Paulo Bento was sent off for arguing with English referee Anthony Taylor for not allowing a corner to be taken despite the 10 minutes having elapsed.
In contrast, elated Black Stars substitutes sprinted onto the pitch to celebrate as fans in the stand blew whistles and danced in celebration.
With Portugal to come next for South Korea, this feels a significant defeat, while Ghana - unfortunate to lose against Portugal - will face Uruguay in good spirits in their final game.