Two people lost their lives at Donkorkrom in the Kwahu Affram Plains North District of the Eastern Region after they allegedly ate puffer fish.
Four others are currently on admission at the Presbyterian hospital at Donkorkrom.
The deceased are 48-year old Forgive Tagbolu and a 71-year-old Veronica Agbobli, who are all residents of Abotanso.
They died on their way to the hospital after complaining of stomach upset.
Those who have been admitted at the hospital are Gracious Tagbolu, Peace Agbobli, Kofi Opare and Agbobli Kofi.
A member of the family, Kofi Agbobli who confirmed the incident to PrimeNewsGhana said the victims bought the fish from a market at Donkorkrom.
Medical Superintendent of the Hospital, Dr. Zimblim Kasule, has also confirmed the incident but said the four are responding to treatment.
Health authorities have recommended their transfer to the Police Hospital in Accra for autopsy.