The Black Stars of Ghana have dropped to 51st in the latest Fifa rankings with Kenya earning 22 points.
Ghana's drop is as a result of their 1-0 lost to Kenya in the 2019 Africa Cup of Nations qualifying.
Kenya after that victory have moved five places to 107th globally.
Tunisia are up one place to 23 in the world to make them the outright top-ranked African nation.
The Carthage Eagles move comes on the back of their 2-0 victory in Swaziland in a Nations Cup tie.
Senegal, who were joint top in August, drop to 25th in the world and 2nd in Africa after they were held to a 2-2 draw in Madagascar in Nations Cup qualifier.
Belgium also gained a place on the rankings to become the joint number one globally alongside World Cup winners France.
Africa's Top 10 on August's Fifa rankings (global position in brackets):
1. Tunisia (23)
2. Senegal (25)
3. DR Congo (40)
4. Morocco (45)
5. Nigeria (48)
6. Cameroon (50)
7. Ghana (51)
8. Burkina Faso (56)
9. Mali (63)
10. Egypt (64)