Manchester United blew a two-goal lead as late own goals from Harry Maguire and Tyrell Malacia handed Sevilla an unlikely lifeline and a 2-2 draw in the first leg of their Europa League quarter-final at Old Trafford.
United appeared to be striding towards the semi-finals after Marcel Sabitzer's first-half double but a failure to underscore their dominance was ruthless punished in a remarkable finale.
Already without topscorer Marcus Rashford, the draw, which will have felt like a defeat, could have come at an even greater cost, with centre-back Raphael Varane forced off injured at half-time and Lisandro Martinez carried from the field on a stretcher in the second half.
It means United's Europa League aspirations hinge on producing a positive result in next Thursday's return at the Ramon Sanchez Pizjuan without their first-choice centre-back partnership and leading scorer.
How Man Utd threw away first-leg advantage
It was a case of no Rashford, no problem for Manchester United as they set about securing a first-leg advantage to take to Seville with an imperious attacking start which Jadon Sancho thought he had crowned with the opener inside 30 seconds, only for it to be ruled out for offside.United's wait for the opener would only last 14 minutes, though, with Fernandes' incisive forward pass finding Sabitzer, who finished clinically past goalkeeper Yassine Bounou after being kept onside by Marcos Acuna.
The lead was doubled seven minutes later, with Sabitzer timing another run in behind and producing another composed finish after the returning Martial's brilliant takedown and defence-splitting pass.
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